E-mail: firstname.lastname@example.org Telephone: +31 53 489 9665 Fax: +31 53 489 3511 Address: Faculty of Science and Technology Medical Cell BioPhysics (MCBP) Building: Carré Room: CR4435
Tarun is currently an Post Doc at the University of Twente, within the Translational Liver Research group. Tarun (M.Sc. in Nanoscience and MTech in Nanotechnology, Amity University, India 2013) is finalizing his PhD that focuses on the evaluation of nanomedicine formulations in tumors with different levels of EPR. During his PhD, he evaluated methods to monitor and modulate angiogenesis, including vascular normalization, in order to improve drug targeting to tumors, and to enhance the efficacy of combination therapies.
Tarun is part of the ‘Targeted (nano)therapeutics/(nano)theranostics for diagnosis and treatment of liver diseases‘ research topic within the Translational Liver Research group. His main field of research is on the bioactive liposomes for the treatment of non-alcoholic fatty liver diseases. Hereby, he aim to incorporate the pro-resolving lipids in liposomes (bioactive liposomes) to improve their solubility and bioavailability. The liposomes will be characterized for their physiochemical properties (size and charge), morphology, stability, pro-resolving lipids release and cellular uptake. He will then evaluate the cellular toxicity and pro-resolving activity of the bioactive liposomes versus free lipids (in the non-liposomal form dissolved in ethanol) in vitro in cell cultures and in 3D spheroids. Subsequently, he will evaluate the most promising bioactive liposomal formulation in vivo in an established NASH mouse model. This project is funded by Phospholipid Research Council grant.